Enemies

Doctor Who is a British science fiction television programme produced by the BBC. The programme depicts the adventures of a mysterious alien time-traveller known as 'the Doctor' who travels in his space and time-ship, the TARDIS, which normally appears from the exterior to be a blue 1950s police box. With his companions, he explores time and space, solving problems, facing monsters and righting wrongs.
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The First Master

Actor: Roger Delgado

A would-be universal conqueror, the Master wants to control the universe (in The Deadly Assassin his ambitions were described as becoming "the master of all matter", and in "The Sound of Drums" he acknowledges that he chose the name "the Master"), with a secondary objective of eliminating and/or hurting the Doctor. The original (and most common before 1996) look of the character was similar to that of the classic Svengali character; a black Nehru outfit with a beard and moustache. He would often use disguises and brainwashing to operate in normal society, while setting up his plans; he also tried to use other alien races and powers as his means to conquest, such as the Autons and the Daemons. Delgado's portrayal of the Master was as a suave, charming and somewhat sociopathic individual, able to be polite and murderous at almost the same time.
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The Second Master

Actor: Anthony Ainley

In many of his appearances opposite the Fifth Doctor, the Master shows his penchant for disguise once again. For example, in Time-Flight he operates under concealment for no clear plot reason. The character's association with playful pseudonyms also continued both within the series and in its publicity: when the production team wished to hide the Master's involvement in a story, they credited the character under an anagrammatic alias such as "Neil Toynay" (Tony Ainley) or "James Stoker" (Master's Joke).
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The Fifth Master

Actor: John Simm

Aspects of Simm's Master parallel Tennant's (Tenth) Doctor, primarily in his ability to make light of tense situations. According to the producers, this was done to make the Master more threatening to the Doctor by having him take one of his opponent's greatest strengths, as well as making the parallels between the two characters more distinctive. In an episode of Doctor Who Confidential, Lords and Masters, Russell T Davies also classifies the Master as both a sociopath and a psychopath.
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The Cybermen

First Faced: The First Doctor

The Cybermen are a fictional race of cyborgs who are amongst the most persistent enemies of the Doctor in the British science fiction television series, Doctor Who. Cybermen were originally a wholly organic species of humanoids originating on Earth's twin planet Mondas that began to implant more and more artificial parts into their bodies as a means of self-preservation. This led to the race becoming coldly logical and calculating, with emotions usually only shown when naked aggression was called for.

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The Daleks

First Faced: The First Doctor

Daleks are organisms from the planet Skaro, integrated within a tank-like or robot-like mechanical casing. The resulting creatures are a powerful race bent on universal conquest and domination, utterly without pity, compassion or remorse. Various storylines portray them as having had every emotion removed except hate, leaving them with a desire to purge the Universe of all non-Dalek life. Very occasionally they are shown as experiencing other emotions, including fear, although such occurrences are rare.

Collectively they are the greatest extraterrestrial enemies of the Time Lord and series protagonist, the Doctor. Their famous catchphrase is "Exterminate!", with each syllable individually screeched in a frantic electronic voice.

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The Weeping Angels

First Faced: The Tenth Doctor

The Weeping Angels are hunters featured in the Tenth Doctor episode, "Blink", and the Eleventh Doctor episodes, "The Time of Angels" and "Flesh and Stone". Their physiology is quantum-locked, so that they only occupy a single position in space when seen by an observer (see Copenhagen interpretation). When they are not observed they become a "quantum wave form" that occupies many positions in space. Therefore, they cannot move while observed, but can move extremely quickly when unseen. They turn to stone when observed, as a defence mechanism, because according to the Doctor, "you can't kill a stone." While in their locked state they resemble stone statues, often covering their eyes so that they will not see each other and lock themselves forever in stone form. Their name is an allusion to this defence mechanism.
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Sontarans

First Faced: The Third Doctor

The Sontarans are a race of belligerent and militaristic clones who waged eternal war throughout the Mutter's Spiral against the Rutan Host.
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The Ood

First Faced: The Tenth Doctor

The Ood are a fictional alien species with telepathic abilities from the long running science fiction series Doctor Who. In the series' narrative, they live in the distant future (circa 42nd century).

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The Silence

First Faced: The Eleventh Doctor

The Silence is a fictional religious order or movement in the British science fiction television series Doctor Who. An alien species associated with this order, referred to only as the Silence, is played primarily by Marnix Van Den Broeke.

The existence of the Silence is a secret because anyone who sees them immediately forgets about them after looking away, but retains suggestions made to them by the Silence. This allows them to have a pervasive influence across human history while being difficult to locate or resist.

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The Crack in Time

First Faced: The Eleventh Doctor

All of time and space coming to an end. That end is in the fire in the crack. In the end the cause was the explosion of the Doctor's TARDIS.